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The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in adults with a body mass index (BMI) of greater than 27, so long as they also have problems with weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (blood pressure).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so when an aid to stop smoking treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle which includes a reduced-calorie dieting and exercise, Contrave provides another treatment selection for chronic weight reduction for people who are obese or are overweight and still have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular exercising. Results from a clinical trial that enrolled patients without diabetes showed that patients had a normal weight loss of four years old.1% in contrast to participants have been given placebos) throughout a 12- month period, while a separate study involving patients with type 2 diabetes had the average weight loss of 2% over treatment with placebo at one year.

Using two separate drugs to lose weight can be very effective there are combinations before the FDA now awaiting approval. When dealing with fat loss and the people that go through it you should err to the side of caution and allow the FDA do its job and demand some research be done so that the public is aware of the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies are in business to generate income and that they would say anything to keep people on their medications.

Researchers found out that participants using this drug for any year, lost weight within one month and have kept the body weight off during the entire 56 weeks in the study. Contrave is really a combination in the drugs naltrexone and bupropion, which seems to reflect a fresh trend of weight-loss drugs which might be made up of more than one active ingredient, which can make them more effective and safer.

Combo-pilling may be the newest fad or in addition to this the newest to come under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is now popular is the fact that by right now there are no long term prescription weight loss supplements that have been licensed by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be approved by the FDA.

Seizures can be a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug could also raise blood pressure level and heartbeat, and shouldn't be used in those with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must 't be used in patients with uncontrolled high blood pressure level, in addition to by a person with heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients with a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients to the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking.


"This could be the first drug I'm mindful of that targets both appetite and reward centres in the brain," he was quoted saying.
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